Letrozole (femara)

Letrozole
(Femara) Letrozole (Femara) is the chemical name of Novartis selective inhibitor of the third generationAromatase (AI). This medicine has been developed to fight against breast cancer by inhibiting aromatization. It is generally used as part of an aggressive treatment of women after menopause to combat and reverse the spread of breast cancer after other treatments (eg tamoxifen therapy) failed. Perhaps the most efficient on the market for this purpose currently (5) It is very similar to the structure and activities of its predecessor Arimidex. Letrozole (Femara) also does a lot of things that would be of interest to bodybuilders and athletes. First, it has been shown to reduce estrogen levels by 98% or more (1). At least one documented case, letrozole (Femara) reduced estrogen in the test subject to undetectable levels and increase LH, FSH and SHBG (4). Of course, this is in the interest of bodybuilders, as less estrogen in the body means less chance of certain side-effects such as water retention, and Gynocomastia acne. This makes letrozole (Femara), an appropriate choice for the most serious bulking or cutting cycles, including heavy androgens. In addition, if you are a competitive bodybuilder, letrozole (Femara), it must be a product of the preparation for competition, no other auxiliary compounds dry and stiff like Letro will. The effective dose of letrozole (Femara) is .25-.5mg/day (I use .25mgs/day), but warned if you exceed this amount, it can kill your libido. It should also be noted that there is a rebound effect on your estrogen outside Letrozole. Maximum inhibition of the enzyme aromatase to be detected at such low doses, as 100mcg! (2) Letrozole (Femara) 'S effects of serum lipids (cholesterol, HDL or LDL), according to a researcher: "inconsistent." It is clear, however, you will eventually suffer from disorders of lipid profile and the immune system, if you keep your estrogen levels too low for too long. Your libido is also likely to suffer from a very low level of estrogen present. As already mentioned, letrozole (Femara) can be used to enhance LH and FSH (which are hormones that signal your testicles to produce more testosterone). It is also, of course, increase your level of testosterone (6) through the mechanism. Again, it is of interest to athletes and bodybuilders for obvious reasons. Letrozole (Femara), of course, can be used for post-cycle therapy (PCT) to raise the level of testing, but for various reasons, tamoxifen May be a better choice. Nevertheless, I have successfully used letrozole (Femara) for this purpose. How is this compared with Aromasin and Arimidex, the other major competitors? Well, not related to the cellular system, letrozole (Femara) is 2.5 times more potent than anastrozole and exemestane in its inhibition of aromatase enzyme and activity, as well as in cellular systems, it is 10-20X stronger! In addition, much time in your body, but takes some time to arrive and letrozole (Femara) is a formidable 2-4 days (!) ½ of life, and you need to take letrozole (Femara) for 60 days for the stability of the blood plasma level (8). These impressive figures, but one of the most interesting things about Letrozole (Femara): This can lead to a reduction / elimination / reverse existing gynocomastia! In a study on mice (* no, I know that is not perfect), gyno-like changes in the mammary gland were totally destroyed! Here's a direct quote from the study: "Our results also indicate aromatase hyperexpression-induced changes in mammary glands can be abrogated [destroyed] with very low concentrations of aromatase inhibitor, letrozole (Femara)." (7) In addition, I used Letro get rid of my gyno, as one of my friend and we both used at a dose of 2.5mgs/day, reducing .25mgs/day, then finally leave. . gyno around and not return to our business. I would say that this material is very high, given its availability and cost (given the fact that .25mgs/day more than adequate protection of estrogen on most cycles related parties), not to mention its usefulness for different functions (destroying gyno, preventing estrogenic sides, as well as for PCT). References: Clin Cancer Res. 2005 April 15, 11 (8) :2809-21. J Clin Endocrinol Metab. 1995 Sep; 80 (9) :2658-60. Eur J Obstet Gynecol Reprod Biol. 2002 Nov 15; 105 (2) :161-5 Epilepsy behavior. April 2004, 5 (2) :260-3 Semin Oncol. December 2004, 31 (6 Suppl 12) :3-8. Diabetes Obes Metab. May 2005, 7 (3) :211-5. J Steroid Biochem Mol Biol. December 2001, 79 (1-5) :27-34. Hyperexpression of aromatase transgenic mice model: cell type specific expression and use of letrozole (Femara) to cancel the milk hyperplasia without affecting normal physiology. (Clin Cancer Res. January 2003, 9 (1 Pt 2): 468S-72S.).